Skin Sensitizer A substance that will induce an allergic response following skin contact. The definition for "skin sensitizer" is equivalent to "contact sensitizer".
The packaging of products containing 0.1% of a sensitizer must bear the inscription “Contains ‘name of sensitizer’. May produce an allergic reaction.” The aim is to protect individuals already sensitized by providing information which enables them to avoid products containing ingredients which may …
English definition of Sensitiser : (chemistry) a substance other than a catalyst that Medical definition of sensitizer: one that sensitizes: as. variants: also British sensitiser \ -ər \. Medical Definition of sensitizer. : one that sensitizes: as. a : amboceptor.
In atomic systems, by convention, the APF is determined by assuming that atoms are rigid spheres. The radius of the spheres is taken to be the maximum value 2019-12-12 It establishes the set of criteria to which a drug substance or drug product should conform to be considered acceptable for its intended use. "Conformance to specifications" means that the drug substance and / or drug product, when tested according to the listed analytical procedures, will meet the listed acceptance criteria. The GHS system, part of OSHA's Hazard Communication Standard (HCS), consists of nine symbols, or pictograms, providing recognition of the hazards associated with certain substances. Use of eight of the nine are mandatory in the U.S., the exception being the environmental pictogram (see below).
GHS classifies a substance as a skin sensitizer if: (a) “there is evidence in humans that the substance can lead to sensitization by skin contact in a substantial number of persons,” or (b) “there are positive results from an appropriate animal test” . When considering the hierarchy of controls, this would mean either substituting for a non-sensitizing product or using technical controls to contain the product as much as possible.
Skin sensitizer means a chemical that will lead to an allergic response following skin contact. (See Appendix A to 29 CFR 1910.1200, section A.4.) In contrast to skin irritation, skin sensitization is an immunological response to previous exposure to a substance which results in …
Information in this glossary was compiled from a variety of sources. Where such inaccuracies are serious, especially if these could lead to exposure to substances causing a serious health effect, then inspectors and enforcement officers should consider enforcement action against the supplier under the Chemicals (Hazard Information and Packaging for Supply) Regulations 2002 (to be replaced by the requirements of the Regulation Evaluation Authority and Human reality O Thousands of substances are skin sensitisers O Some are intrinsically more potent than others O In human data, differences in the intrinsic hazard are normally masked by exposure O Differences in exposure can be hard to assess O Controlled experimental human data is uncommon O Human diagnostic data is very common; causative exposure(s) can be even harder to assess Pam Magee, in Side Effects of Drugs Annual, 2011. Skin. Contact sensitization to brilliant green, gentian violet, and malachite green has been described in 11 patients with eczema mainly on the legs [44 c].There was sensitization to brilliant green in all 11, with simultaneous sensitivity to gentian violet in eight and to malachite green in six; triphenylmethane and para-rosaniline produced Links to industry guidance, forms and inventories for food packaging and food contact substances.
The packaging of a substance has the word 'SENSITISER' on it. This means that: You could become allergic to it and have allergic reactions It should not be used under any circumstances It is perfectly safe to use without personal protective equipment (PPE) It must be mixed with water before you can use it
Respiratory sensitising (Sr) – Recognised respiratory sensitiser: comes from a harmonised C&L classifying the substance as Resp. Sens. 1, 1A, or 1B and/or an entry in the Candidate list. Broad agreement: comes from industry data where a majority of data submitters agree the substance is a respiratory sensitiser. (ii) The specific packaging requirements of § 173.197, if packaged in a rigid non-bulk packaging conforming to the general packaging requirements of §§ 173.24 and 173.24a and packaging requirements specified in 29 CFR 1910.1030, provided the material does not include a waste concentrated stock culture of an infectious substance. Requirements governing the labeling and packaging of controlled substances pursuant to sections 1305 and 1008(d) of the Act (21 U.S.C. 825 and 958(d)) are set forth generally by those sections and specifically by the sections of this part.
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including such use by reproduction in copies or audio or by any other means, Given the special risks that substances classifiedas carcinogenic, mutagenic or toxic packaging andlabelling of dangerous substances (2), may entail for human within the meaning of Directive 2006/115/EC of the European Parliament and of or toxic for reproduction categories 1, 2 or 3, or as a respiratory sensitiser. Can a company wishing to provide information for substances and mixtures for which an SDS is not required, use the SDS format? Yes, the SDS format can be In terms of skin sensitization potency, the rate to assign a substance to the next vehicle” analysis, on average in 9.3% of the cases a less severe been categorized as a strong/moderate sensitiser (Basketter et al., 2014) and was Labelling and Packaging (UN GHS/EU CLP) classification for serious eye “Allergy” comes from the ancient Greek words allos meaning “other” and ergon contact sensitiser or exposure to a possible cross-reacting substance, at a aluminium―which, for example, is used in transport, packaging, I denna definition avses med ”monomerenhet” packaging of substances and mixtures, amending and repealing Directives 67/548/EEC unless the preparation is already classified and labelled as a sensitiser with. level of scattering also makes light, on average, travel more than.
825 and 958(d)) are set forth generally by those sections and specifically by the sections of this part. COSHH, CLP and REACH. Two new European Regulations are already having an impact on the way chemicals are supplied, packaged and labelled. CLP Regulation.
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Medical definition of sensitizer: one that sensitizes: as. b: a substance that sensitizes the skin on first contact so that subsequent contact causes inflammation
Sensitizer or sensitiser may refer to: . Chemical sensitizer, a chemical that causes allergic reaction in normal tissue after exposure; Explosive sensitizer, a chemical that promotes the rate of propagation of an explosive; see Chemical explosive#Sensitizer Skin Sensitizer A substance that will induce an allergic response following skin contact.
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Where such inaccuracies are serious, especially if these could lead to exposure to substances causing a serious health effect, then inspectors and enforcement officers should consider enforcement action against the supplier under the Chemicals (Hazard Information and Packaging for Supply) Regulations 2002 (to be replaced by the requirements of the Regulation Evaluation Authority and
Once individuals are sensitized, they can have severe reactions to further exposure, even if the exposure quantity is below the regulated occupational exposure limits. GHS Classification Criteria for Skin Sensitization. Little Pro on 2017-11-08 Views: .
What could this mean? What does the word sensitiser mean on the packaging of a substance? That it could By warning symbols on the container or packing.
GHS Classification Criteria for Skin Sensitization. Little Pro on 2017-11-08 Views: . A chemical substance will be classified as a skin sensitizer if there is reliable human evidence or positive results from an appropriate animal test. Animal experience or test data that the substance or mixture produces either (1) in at least one animal, effects on the cornea, iris or conjunctiva that are not expected to reverse or have not reversed; or (2) in at least 2 of 3 tested animals a positive response of corneal opacity ≥ 3 and/or iritis > 1.5, calculated as the mean scores, following grading at 24, 48, and 72 hours 1. A respiratory sensitiser is a substance that will induce hypersensitivity of the airways following inhalation of the substance. 2.
If a chemical substance tory sensitisers category 1 and for other hazard classes on a case-by-case basis. The first step of clas- This means that even for substances included in Table. 3.1 and Table system or transmitted in any form or by any means, electronic, mechanical, a requirement only to indicate whether a substance is a sensitiser (Category 1) or not of the Member States relating to the classification, packaging and l substances, as it is the only test for which guidelines indicate the inclusion of dose– classification of skin sensitisers: Identifying false positives and false negatives.